Kinase Inhibitor Drugs (Wiley Series in Drug Discovery and by Rongshi Li,Jeffrey A. Stafford

By Rongshi Li,Jeffrey A. Stafford

A accomplished source on case stories of advertised kinase medicines and promising drug trials

Since the invention of protein kinase task in 1954, the sphere of protein kinase drug discovery has complex dramatically. With the continued scientific good fortune of the Bcr-Abl kinase inhibitor Gleevec within the remedy of power myelogenous leukemia and 7 extra advertised kinase inhibitor medicinal drugs, researchers have compelling facts that kinase inhibitors should be hugely efficacious within the remedy of ailments as a result of aberrant task of protein kinase. presently greater than a hundred protein kinase inhibitors are in medical development.

In one entire quantity, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, current well timed and critical case experiences of advertised kinase medicines and several other of the main complicated kinase inhibitors in scientific trials. Kinase Inhibitor Drugs includes:

  • Case reports from prime investigators and specialists within the box that offer firsthand money owed of kinase inhibitor discovery

  • Current considering on kinase constitution, biochemistry, and sign transduction pathways

  • Information on state of the art applied sciences and instruments comparable to structure-based and fragment-based drug discovery

  • A lineup of clinical-phase development issue receptor inhibitors

  • Inhibitors of phone cycle kinases

  • The discovery of allosteric inhibitors of MEK kinase

  • Information on pharmacogenomics and its program to kinase inhibitor medical development

Show description

Read Online or Download Kinase Inhibitor Drugs (Wiley Series in Drug Discovery and Development) PDF

Best pharmacology books

Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs (Drugs and the Pharmaceutical Sciences)

Oral lipid-based formulations are attracting substantial consciousness as a result of their potential to facilitate gastrointestinal absorption and decrease or get rid of the impact of meals at the absorption of poorly water-soluble, lipophilic medications. regardless of the most obvious and proven software of those formulations for addressing a continual and starting to be challenge of significant value, the pharmaceutical has been sluggish to use and additional advance this expertise.

Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies

Biopharmaceutical drugs, the most recent category of therapeutics, are relatively heterogeneous and contain a number of molecules akin to proteins, peptides, vaccines and nucleic acids, with use in almost all healing fields (e. g. melanoma and infectious ailments, vaccination, metabolic dysfunctions) and diagnostics.

Pharmacological Basis of Acute Care

This booklet is the 4th in a sequence of Acute Care books written with the purpose to handle the desires of future health care services while dealing with the acutely in poor health sufferers. Globally it has develop into obvious that the learn of pharmacology and next medical education has no longer continuously accurately outfitted younger medical professionals having the ability to administer medicinal drugs to their sufferers effectively and with a bit of luck, relatively within the seriously ailing sufferer.

Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery

The following, front-line researchers within the booming box of nanobiotechnology describe the main promising ways for bioinspired drug supply, encompassing small molecule supply, supply of healing proteins and gene supply. The providers surveyed contain polymeric, proteinaceous and lipid structures at the nanoscale, with a spotlight on their adaptability for various cargoes and goal tissues.

Additional resources for Kinase Inhibitor Drugs (Wiley Series in Drug Discovery and Development)

Example text

Download PDF sample

Rated 5.00 of 5 – based on 30 votes