By Rongshi Li,Jeffrey A. Stafford
Since the invention of protein kinase task in 1954, the sphere of protein kinase drug discovery has complex dramatically. With the continued scientific good fortune of the Bcr-Abl kinase inhibitor Gleevec within the remedy of power myelogenous leukemia and 7 extra advertised kinase inhibitor medicinal drugs, researchers have compelling facts that kinase inhibitors should be hugely efficacious within the remedy of ailments as a result of aberrant task of protein kinase. presently greater than a hundred protein kinase inhibitors are in medical development.
In one entire quantity, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, current well timed and critical case experiences of advertised kinase medicines and several other of the main complicated kinase inhibitors in scientific trials. Kinase Inhibitor Drugs includes:
Case reports from prime investigators and specialists within the box that offer firsthand money owed of kinase inhibitor discovery
Current considering on kinase constitution, biochemistry, and sign transduction pathways
Information on state of the art applied sciences and instruments comparable to structure-based and fragment-based drug discovery
A lineup of clinical-phase development issue receptor inhibitors
Inhibitors of phone cycle kinases
The discovery of allosteric inhibitors of MEK kinase
Information on pharmacogenomics and its program to kinase inhibitor medical development
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