By Alex Avdeef
Explains the way to practice and examine the result of the newest physicochemical methods
With this booklet as their advisor, readers have entry to all of the present info had to completely examine and appropriately ensure a compound's pharmaceutical homes and their results on drug absorption. The publication emphasizes oral absorption, explaining all of the physicochemical equipment used at the present time to investigate drug applicants. additionally, the writer offers specialist information to aid readers examine the result of their reports in an effort to choose the main promising drug candidates.
This Second Edition has been completely up-to-date and revised, incorporating all of the newest examine findings, equipment, and assets, including:
Descriptions and purposes of recent PAMPA versions, drawing on greater than thirty papers released by way of the author's study group
Two new chapters studying permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded details and strategies to aid pKa determination
New examples explaining the therapy of virtually insoluble try compounds
Additional case reports demonstrating using the newest physicochemical techniques
New, revised, and multiplied database tables through the book
Well over 2 hundred drawings support readers larger comprehend tough techniques and supply a visible advisor to advanced techniques. additionally, over 800 references function a gateway to the first literature within the box, facilitating additional learn into all of the issues coated within the book.
This Second Edition is suggested as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different comparable parts of analysis. it's also suggested as a supplemental textual content for graduate classes in pharmaceutics.
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